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Their effect on body composition in research is driven substantially through reduced energy intake and improved insulin dynamics, not through direct action on fat cells

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Further reading: Mounjaro results In the TRIUMPH-1 trial, retatrutide helped people lose 28.3% of their starting body weight at 80 weeks on the 12mg dose

That combination gastric origin, enzymatic stability, and remarkable tissue breadth is what has driven decades of continuous preclinical research interest in this unique compound